Artificial intelligence in retinopathy of prematurity: transfer learning and federated learning
DOI:
https://doi.org/10.12809/hkjo-v28n1-386Keywords:
Artificial intelligence, Deep learning, Machine learning, Retinopathy of prematurityAbstract
Artificial intelligence can help resolve the lack of specialists in retinopathy of prematurity (ROP) and its associated diagnostic subjectivity. Obstacles to the use of deep learning (DL) for ROP tasks include the condition’s low prevalence, data paucity, and difficulty in multiinstitutional data sharing to optimize training. Transfer learning (TL) and federated learning (FL) are advanced strategies to address DL issues. This review highlights the advantages of TL and FL applications in various ROP-related tasks. TL and FL achieve outstanding results for ROP screening, triaging, and monitoring, with certain algorithms exceeding the baseline DL models. TL assists the construction of generalizable ROP models
despite little data. FL lays the groundwork for safe data exchange between institutions in TL. However, both TL and FL entail shortcomings associated with inadequate generalizability and data privacy attacks. Further research is needed to address the unsolved interpretability and liability issues in TL and FL models. Although both TL and FL have great potential to overcome DL constraints and improve the diagnosis of ROP, more work is needed to address application concerns such as model interpretability and liability.
References
1. Dogra MR, Katoch D, Dogra M. An update on retinopathy of prematurity (ROP). Indian J Pediatr 2017;84:930-6.
2. Kumar V, Patel H, Paul K, Surve A, Azad S, Chawla R. Deep learning assisted retinopathy of prematurity screening technique. HEALTHINF 2021;234-43.
3. Multicenter trial of cryotherapy for retinopathy of prematurity. One-year outcome--structure and function. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Arch Ophthalmol 1990;108:1408-16.
4. Good WV, Early Treatment for Retinopathy of Prematurity Cooperative Group. Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial. Trans Am Ophthalmol Soc 2004;102:233-50.
5. Blencowe H, Lawn JE, Vazquez T, Fielder A, Gilbert C. Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010. Pediatr Res 2013;74(Suppl 1):35-49.
6. Campbell JP, Chiang MF, Chen JS, et al. Artificial intelligence for retinopathy of prematurity: validation of a vascular severity scale against international expert diagnosis. Ophthalmology 2022;129:e69-76.
7. Campbell JP, Ryan MC, Lore E, et al. Diagnostic discrepancies in retinopathy of prematurity classification. Ophthalmology 2016;123:1795-801.
8. Prakalapakorn SG, Greenberg L, Edwards EM, Ehret DEY. Trends in retinopathy of prematurity screening and treatment: 2008-2018. Pediatrics 2021;147:e2020039966.
9. Fleck BW, Williams C, Juszczak E, et al. An international comparison of retinopathy of prematurity grading performance within the Benefits of Oxygen Saturation Targeting II trials. Eye 2018;32:74-80.
10. Gschließer A, Stifter E, Neumayer T, et al. Inter-expert and intra-expert agreement on the diagnosis and treatment of retinopathy of prematurity. Am J Ophthalmol 2015;160:553-60.e3.
11. Chiang MF, Jiang L, Gelman R, Du YE, Flynn JT. Interexpert agreement of plus disease diagnosis in retinopathy of prematurity. Arch Ophthalmol 2007;125:875-80.
12. Peng Y, Chen Z, Zhu W, et al. ADS-Net: attention-awareness and deep supervision based network for automatic detection of retinopathy of prematurity. Biomed Opt Express 2022;13:4087-101.
13. Tan Z, Simkin S, Lai C, Dai S. Deep learning algorithm for automated diagnosis of retinopathy of prematurity plus disease. Transl Vis Sci Technol 2019;8:23.
14. Ting DSW, Pasquale LR, Peng L, et al. Artificial intelligence and deep learning in ophthalmology. Br J Ophthalmol 2019;103:167-75.
15. Scruggs BA, Chan RVP, Kalpathy-Cramer J, Chiang MF, Campbell JP. Artificial intelligence in retinopathy of prematurity diagnosis. Transl Vis Sci Technol 2020;9:5.
16. Gensure RH, Chiang MF, Campbell JP. Artificial intelligence for retinopathy of prematurity. Curr Opin Ophthalmol 2020;31:312-7.
17. Ramanathan A, Athikarisamy SE, Lam GC. Artificial intelligence for the diagnosis of retinopathy of prematurity: a systematic review of current algorithms. Eye 2023;37:2518-26.
18. Indolia S, Goswami AK, Mishra SP, Asopa P. Conceptual understanding of convolutional neural network: a deep learning approach. Procedia Comput Sci 2018;132:679-88.
19. Taye MM. Theoretical understanding of convolutional neural network: concepts, architectures, applications, future directions. Computation 2023;11:52.
20. Anwar A. Difference between AlexNet, VGGNet, ResNet, and inception. Towards Data Science. Accessed 27 July 2024. Available from: https://towardsdatascience.com/the-w3h-of-alexnet-vggnet-resnet-and-inception-7baaaecccc96.
21. Nabil M. Unveiling the diversity: A comprehensive guide to types of CNN architectures Medium. Accessed 27 July 2024. Available from: https://medium.com/@navarai/unveiling-the-diversity-a-comprehensive-guide-to-types-of-cnn-architectures-9d70da0b4521.
22. Maitra P, Shah PK, Campbell PJ, Rishi P. The scope of artificial intelligence in retinopathy of prematurity (ROP) management. Indian J Ophthalmol 2024;72:931-4.
23. Bai A, Carty C, Dai S. Performance of deep-learning artificial intelligence algorithms in detecting retinopathy of prematurity: a systematic review. Saudi J Ophthalmol 2022;36:296-307.
24. Kairouz P, McMahan HB, Avent B, et al. Advances and open problems in federated learning. Foundations Trends Machine Learning 2021;14:1-210.
25. Federated learning. Wikipedia. Accessed 27 July 2024. Available from: https://en.wikipedia.org/w/index.php?title=Federated_learning&oldid=1236419947.
26. Coyner AS, Chen JS, Chang K, et al. synthetic medical images for robust, privacy-preserving training of artificial intelligence: application to retinopathy of prematurity diagnosis. Ophthalmol Sci 2022;2:100126.
27. Kalpathy-Cramer J, Campbell JP, Erdogmus D, et al. Plus disease in retinopathy of prematurity: improving diagnosis by ranking disease severity and using quantitative image analysis. Ophthalmology 2016;123:2345-51.
28. Ruamviboonsuk P, Kaothanthong N, Ruamviboonsuk V, Theeramunkong T. Transfer Learning for Artificial Intelligence in Ophthalmology. In: Yogesan K, Goldschmidt L, Cuadros J, Ricur G, editors. Digital Eye Care and Teleophthalmology: a Practical Guide to Applications. Springer International Publishing; 2023: 181-98.
29. Al-Timemy AH, Ghaeb NH, Mosa ZM, Escudero J. Deep transfer learning for improved detection of keratoconus using corneal topographic maps. Cognit Comput 2022;14:1627-42.
30. Rao DP, Savoy FM, Tan JZE, et al. Development and validation of an artificial intelligence based screening tool for detection of retinopathy of prematurity in a South Indian population. Front Pediatr 2023;11:1197237.
31. Wang J, Ju R, Chen Y, et al. Automated retinopathy of prematurity screening using deep neural networks. EBioMedicine 2018;35:361-8.
32. Chen JS, Coyner AS, Ostmo S, et al. Deep learning for the diagnosis of stage in retinopathy of prematurity: accuracy and generalizability across populations and cameras. Ophthalmol Retina 2021;5:1027-35.
33. Subramaniam A, Orge F, Douglass M, et al. Image harmonization and deep learning automated classification of plus disease in retinopathy of prematurity. J Med Imaging (Bellingham) 2023;10:061107.
34. Brown JM, Campbell JP, Beers A, et al. Automated diagnosis of plus disease in retinopathy of prematurity using deep convolutional neural networks. JAMA Ophthalmol 2018;136:803-10.
35. Mao J, Luo Y, Liu L, et al. Automated diagnosis and quantitative analysis of plus disease in retinopathy of prematurity based on deep convolutional neural networks. Acta Ophthalmol 2020;98:e339-45.
36. Understanding the quadratic weighted kappa. Kaggle. Accessed 17 July 2024. Available from: https://www.kaggle.com/code/reighns/understanding-the-quadratic-weighted-kappa.
37. Yildiz VM, Tian P, Yildiz I, et al. Plus disease in retinopathy of prematurity: convolutional neural network performance using a combined neural network and feature extraction approach. Transl Vis Sci Technol 2020;9:10.
38. Tong Y, Lu W, Deng QQ, Chen C, Shen Y. Automated identification of retinopathy of prematurity by image-based deep learning. Eye Vis (Lond) 2020;7:40.
39. Cadrin-Chênevert A. Moving from ImageNet to RadImageNet for improved transfer learning and generalizability. Radiol Artif Intell 2022;4:e220126.
40. Ayana G, Dese K, Choe SW. Transfer learning in breast cancer diagnoses via ultrasound imaging. Cancers (Basel) 2021;13:738.
41. Iman M, Arabnia HR, Rasheed K. A review of deep transfer learning and recent advancements. Technologies 2023;11:40.
42. Li W, Huang R, Li J, et al. A perspective survey on deep transfer learning for fault diagnosis in industrial scenarios: theories, applications and challenges. Mech Syst Signal Process 2022;167:108487.
43. Campbell JP, Lee AY, Abràmoff M, et al. Reporting guidelines for artificial intelligence in medical research. Ophthalmology 2020;127:1596-9.
44. Ting DSW, Wong TY, Park KH, Cheung CY, Tham CC, Lam DSC. Ocular Imaging Standardization for Artificial Intelligence Applications in Ophthalmology: the joint position statement and recommendations from the Asia-Pacific Academy of Ophthalmology and the Asia-Pacific Ocular Imaging Society. Asia Pac J Ophthalmol (Phila) 2021;10:348-9.
45. Tom E, Keane PA, Blazes M, et al. Protecting data privacy in the age of ai-enabled ophthalmology. Transl Vis Sci Technol 2020;9:36.
46. Chang K, Balachandar N, Lam C, et al. Distributed deep learning networks among institutions for medical imaging. J Am Med Inform Assoc 2018;25:945-54.
47. Yang Z, Chen M, Wong KK, Poor HV, Cui S. Federated learning for 6G: applications, challenges, and opportunities. Proc Est Acad Sci Eng 2022;8:33-41.
48. Konečný J, Brendan McMahan H, Yu FX, Richtárik P, Suresh AT, Bacon D. Federated learning: strategies for improving communication efficiency. Accessed 27 July 2024. Available from: http://arxiv.org/abs/1610.05492.
49. Rieke N, Hancox J, Li W, et al. The future of digital health with federated learning. NPJ Digit Med 2020;3:119.
50. Lu C, Hanif A, Singh P, et al. Federated learning for multicenter collaboration in ophthalmology: improving classification performance in retinopathy of prematurity. Ophthalmol Retina 2022;6:657-63.
51. Hanif A, Lu C, Chang K, et al. Federated learning for multicenter collaboration in ophthalmology: implications for clinical diagnosis and disease epidemiology. Ophthalmol Retina 2022;6:650-6.
52. Redd TK, Campbell JP, Brown JM, et al. Evaluation of a deep learning image assessment system for detecting severe retinopathy of prematurity. Br J Ophthalmol 2018:bjophthalmol-2018-313156.
53. Sharafi SM, Ebrahimiadib N, Roohipourmoallai R, Farahani AD, Fooladi MI, Khalili Pour E. Automated diagnosis of plus disease in retinopathy of prematurity using quantification of vessels characteristics. Sci Rep 2024;14:6375.
54. Ryan MC, Ostmo S, Jonas K, et al. Development and evaluation of reference standards for image-based telemedicine diagnosis and clinical research studies in ophthalmology. AMIA Annu Symp Proc 2014;2014:1902-10.
55. Bellemo V, Lim ZW, Lim G, et al. Artificial intelligence using deep learning to screen for referable and vision-threatening diabetic retinopathy in Africa: a clinical validation study. Lancet Digit Health 2019;1:e35-44.
56. Ting DSW, Wu WC, Toth C. Deep learning for retinopathy of prematurity screening. Br J Ophthalmol 2018:bjophthalmol-2018-313290.
57. Taylor S, Brown JM, Gupta K, et al. Monitoring disease progression with a quantitative severity scale for retinopathy of prematurity using deep learning. JAMA Ophthalmol 2019;137:1022-8.
58. Greenwald MF, Danford ID, Shahrawat M, et al. Evaluation of artificial intelligence-based telemedicine screening for retinopathy of prematurity. J AAPOS 2020;24:160-2.
59. Campbell JP, Singh P, Redd TK, et al. Applications of artificial intelligence for retinopathy of prematurity screening. Pediatrics 2021;147:e2020016618.
60. Li Z, Wang L, Wu X, et al. Artificial intelligence in ophthalmology: The path to the real-world clinic. Cell Rep Med 2023;4:101095.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Hong Kong Journal of Ophthalmology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Journal has a fully Open Access policy and publishes all articles under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. For any use other than that permitted by this license, written permission must be obtained from the Journal.