Development of herbal molecules in treating autoimmune uveitis: a narrative review

Authors

  • Chak Yin Justin Leung The Chinese University of Hong Kong
  • Zheng Xi Austin Tang The Chinese University of Hong Kong
  • Chun Bon Wong The Chinese University of Hong Kong
  • Hei Nga Wong The Chinese University of Hong Kong
  • Wai Kit Chu The Chinese University of Hong Kong

Keywords:

Caffeic acid phenethyl ester, Curcumin, Epigallocatechin gallate, Longdan Xiegan Tang, Peony root extract, Triptolide, Uveitis

Abstract

Current treatments for autoimmune uveitis involve the use of corticosteroids topically, locally (including subconjunctival, subtenon, orbital floor, and intraouclar injection), and systemically to attenuate the T cell–mediated response by impairing cell trafficking and activation to the uvea and dampening cell response to ocular antigens. However, long-term local injection of corticosteroids may result in raised intraocular pressure, cataracts, and glaucoma. Systemic use of steroids may result in severe morbidity. Immunomodulatory agents and biologics can circumvent some of these issues but may result in other adverse effects. Herbal molecules are potentially useful in treatment of autoimmune uveitis. We review the literature about the pathogenesis of autoimmune uveitis and the mechanisms, efficacy, and safety of herbal molecules (curcumin, green tea, triptolide, caffeic acid phenethyl ester, total glucosides of peony, and Longdan Xiegan Tang) as a therapeutic option or supplement for autoimmune uveitis.

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Published

2021-12-23

How to Cite

1.
Leung CYJ, Tang ZXA, Wong CB, Wong HN, Chu WK. Development of herbal molecules in treating autoimmune uveitis: a narrative review. Hong Kong J Ophthalmol [Internet]. 2021Dec.23 [cited 2022Jan.20];25(2). Available from: https://hkjo.hk/index.php/hkjo/article/view/307

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Review Articles