An experimental autoimmune uveoretinitis model and intraocular inflammation

Abstract

Intraocular inflammation is one of the leading causes of vision damage. Human uveitis is a group of conditions characterized by inflammatory lesions of intraocular structures. Many cases are idiopathic and can be classified as infectious uveitis or autoimmunerelated uveitis. Compared with infectious uveitis, our knowledge of and treatment options for autoimmunerelated uveitis remain very limited. In order to develop effective therapeutic strategies and agents, it is essential to explore the basic mechanisms and pathogenesis of autoimmune ocular diseases. An experimental autoimmune uveoretinitis animal model has been widely used to study the physiopathogenesis of autoimmune inflammation. The present review describes the characteristics of experimental autoimmune uveoretinitis, as well as the research on intraocular inflammation using this animal model.