Update on the management of non- infectious uveitis

Authors

  • Danny Ng Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong
  • Shaheeda Mohamed Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong
  • Wai-kit Chu Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong
  • Fiona OJ Luk Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong
  • Mårten Brelén Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong
  • Carmen KM Chan Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong

Abstract

Uveitis is inflammation of the anterior, intermediate and/or posterior part of the uvea — the pigmented vascular coat of the eye. It can be infectious or non- infectious, idiopathic or secondary to systemic conditions. Uveitis has a wide range of presentations, from asymptomatic to rapidly sight-threatening disease, and can lead to permanent vision loss in the absence of early therapy. Ethnicity, genetics and the environment can account for regional variations in patterns of uveitis. Management of uveitis remains a challenge because of the diverse heterogeneity in presentation, and a paucity of randomized controlled trials evaluating different drug regimens. Despite being the mainstay of therapy for uveitis, corticosteroid monotherapy is increasingly viewed as unsuitable due to its significant side-effects. A stepwise approach is often adopted whereby least-to-more aggressive forms of therapy are trialed to induce remission. Treatment regimens are shifting from low-dose chronic corticosteroids for maintenance to medium-to-high-dose therapy to control acute inflammation, followed by rapid initiation of immunomodulatory therapy or biologics. This review provides a comprehensive overview of the challenges in managing patients with uveitis, as well as important advances in its investigations and treatment.

Downloads

Published

2016-11-01

How to Cite

1.
Ng D, Mohamed S, Chu W- kit, Luk FO, Brelén M, Chan CK. Update on the management of non- infectious uveitis. Hong Kong J Ophthalmol [Internet]. 2016Nov.1 [cited 2024May21];20(3):95-105. Available from: https://hkjo.hk/index.php/hkjo/article/view/216

Issue

Section

Review Articles

Most read articles by the same author(s)

1 2 > >>