A randomized trial evaluating the effectiveness of ondansetron for postoperative nausea and vomiting in ophthalmic surgeries

Authors

  • Tarun Sharma Sankara Nethralaya, Vision Research Foundation, India.
  • Sengamedu S Badrinath Sankara Nethralaya, Vision Research Foundation, India.
  • Sandip K Saha Sankara Nethralaya, Vision Research Foundation, India.
  • Bickol N Mukesh Sankara Nethralaya, Vision Research Foundation, India.
  • Lekha Gopal Sankara Nethralaya, Vision Research Foundation, India.
  • Gaddam V Sailender Sankara Nethralaya, Vision Research Foundation, India.
  • Ian Sunderraj Sankara Nethralaya, Vision Research Foundation, India.
  • Bhanulakshmi I Mohan Sankara Nethralaya, Vision Research Foundation, India.

Abstract

Aim: To determine the efficacy of intravenous ondansetron in the prevention of postoperative nausea and vomiting (PONY) in patients undergoing ophthalmic surgeries under general anesthesia.

Materials and methods: Five hundred patients, receiving endotracheal anesthesia were randomized either to no drug (group I, n=250) or single dose, intravenous ondansetron just prior to induction (group IIa, n=125) or prior to reversal at the conclusion of surgery (group IIb, n= 125). 

Results: In the first 24 hours postoperatively, the incidence of nausea and vomiting was 20% and 47.2% respectively in control group I, 23.3% and 42.4% in group IIa, and 5.6% and 31.2% in group IIb (p=0.001,0.003). The mean number of nausea and vomiting episodes per patient declined significantly in group IIb, compared to the controls (p=0.001, 0.004). No differences were observed in group IIa. 

Conclusion: Ondansetron administered intravenously at the conclusion of ophthalmic surgery reduces the occurrence of postoperative nausea and vomiting.

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Published

1997-12-01

How to Cite

1.
Sharma T, Badrinath SS, Saha SK, Mukesh BN, Gopal L, Sailender GV, Sunderraj I, Mohan BI. A randomized trial evaluating the effectiveness of ondansetron for postoperative nausea and vomiting in ophthalmic surgeries. Hong Kong J Ophthalmol [Internet]. 1997Dec.1 [cited 2021Feb.25];1(3):115-9. Available from: https://hkjo.hk/index.php/hkjo/article/view/191

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Original Articles