Demyelinating and inflammatory optic neuropathies: an update

Alison YY Chan, Kenneth HL Liu, Jonathan CH Ho, Simon TC Ko

Abstract


Optic neuritis is one of the leading causes of vision loss in young to middle-age populations worldwide. Although it has been documented to account for the initial presentation in up to one-fifth of multiple sclerosis patients among Caucasian populations, the clinical course and etiologies of the condition are less
well-defined in Asians. Chinese patients have lower conversion rates to multiple sclerosis as well as a higher incidence of neuromyelitis optica–associated optic neuritis and optic perineuritis, demonstrating considerable ethnic differences. The need to better characterize the differentiating features between three clinically similar entities: multiple sclerosis–associated optic neuritis, neuromyelitis optica–associated optic neuritis and optic perineuritis, is warranted to facilitate proper management.


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